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Search Result

Search Results for " vascular endothelium "

Targets

Integrin Complement System

15

Compounds

3

Natural Products

16

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T3638 Leukadherin-1 Integrin , Complement System
Leukadherin-1 is an allosteric activator of CD11b/CD18. Increasing CD11b/CD18-dependent cell adhesion to fibrinogen, Decreasing leukocyte motility and transendothelial migration; reduces inflammation.
T34541 SB-209670 SB 209670 Endothelin Receptor
SB-209670 is a selective endothelin receptor antagonist that inhibits the activity of ET(B) receptors in rat vascular endothelium and vascular smooth muscle.
T6264 Bosentan Actelion,Ro 47-0203,Benzenesulfonamide Endothelin Receptor
Bosentan (Benzenesulfonamide) is a sulfonamide-derived, competitive and specific endothelin receptor antagonist with a slightly higher affinity for the endothelin A receptor than endothelin B receptor. Bosentan blocks th...
T4567 Sulfaphenazole Plisulfan,Raziosulfa,Depocid,Depotsulfonamide P450 , Antibacterial
Sulfaphenazole (Plisulfan) is an inhibitor of CYP2C9 (Ki: 0.3 μM) that demonstrates at least 100-fold selectivity over other CYP450 isoforms (Ki: 63/29 μM for CYP2C8/CYP2C18, respectively, and no activity at CYP1A1, CYP1...
T76841 Enlimomab
Enlimomab (BI-RR 0001), a murine IgG2a monoclonal antibody targeting human ICAM-1, reduces leukocyte adhesion to the vascular endothelium, thus diminishing leukocyte extravasation and inflammatory tissue damage. This com...
T75154 ATU027
ATU027, a small interfering RNA (siRNA), silences protein kinase N3 (PKN3) expression in the vascular endothelium. It has been demonstrated to thwart local tumor invasion, as well as lymph node and pulmonary metastasis, ...
T36150 14,15-EE-5(Z)-E
Epoxyeicosatrienoic acids (EETs), such as 11(12)-EET and 14(15)-EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-derived hyperpolarizing factors with vasodilator activity....
T70903 KRH102053
KRH102053 is a HIF-1alpha inhibitor. KRH102053 decreased the protein level of HIF-1alpha and the mRNA levels of HIF-regulated downstream target genes, such as vascular endothelial growth factor, aldolase A, enolase 1 an...
T35464 (±)14(15)-EET-SI
Arachidonic acid is metabolized in the vascular endothelium to epoxytrienoic acids (EETs or EpETrEs) by cytochrome P450 enzymes. The EETs are released in response to acetylcholine, bradykinin, arachidonic acid, or cyclic...
T68511 KRH102140
KRH102140 is a potent activator of PHD2. KRH102140, which has a structure similar to KRH102053. KRH102140 more efficiently suppressed HIF-1α than KRH102053 in human osteosarcoma cells under hypoxia. Furthermore, KRH10214...
T82683 Connexin mimetic peptide 40GAP27
Connexin mimetic peptide 40GAP27, corresponding to the GAP27 domain of the second extracellular loop of the dominant vascular connexin (Cx40), designated as 40Gap27, is a biologically active peptide utilized to study the...
T37234 (±)14(15)-EpETE
EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-de...
T37235 (±)16(17)-EpDPA (±)16,17-EpDPE,(±)16,17 EDP,(±)16,17-epoxy Docosapentaenoic Acid,(±)16,17-epoxy DPA,(±)16(17)-EpDPA
EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-de...
T37238 (±)19(20)-EpDPA
EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-de...
T82684 Connexin mimetic peptide 40,37GAP26
Connexin mimetic peptide 40,37GAP26, a biologically active peptide, matches the GAP26 domain of the extracellular loop of major vascular connexins Cx37 and Cx40, referred to as 37,40Gap26 based on Cx homology. It has bee...
Cat No. Product Name Synonyms Targets
TN1567 Delphinidin chloride Estrogen Receptor/ERR , VEGFR
Delphinidin chloride, a natural plant pigment found in berries and red wine, is a precursor of certain anthocyanins. Delphinidin chloride induces the release of nitric oxide from the vascular endothelium, resulting in va...
T37974 (S)-Coriolic acid 13(S)-HODE Lipoxygenase , Mitochondrial Metabolism , PPAR
(S)-Coriolic acid (13(S)-HODE) is an important intracellular signaling agent, generated by the reaction of linoleic acid with plant and mammalian lipoxygenases, and is involved in cell proliferation and differentiation i...
T3794 Pentagalloylglucose Penta-O-galloyl-β-D-glucose,1,2,3,4,6-O-Pentagalloylglucose,1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose Influenza Virus
1, 2, 3, 4, 6-Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) and gallic acid from Pistacia lentiscus have antimutagenic and antioxidant activities. 2. 1, 2, 3, 4, 6-Penta-O-galloyl-beta-D-glucose (PGG) possesses poten...

Natural Products

Delphinidin chloride
TN1567
Synonym:
Target: Estrogen Receptor/ERR, VEGFR
(S)-Coriolic acid
T37974
Synonym: 13(S)-HODE
Target: Lipoxygenase, Mitochondrial Metabolism, PPAR
Pentagalloylglucose
T3794
Synonym: Penta-O-galloyl-β-D-glucose,1,2,3,4,6-O-Pentagalloylglucose,1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose
Target: Influenza Virus

Recombinant Proteins

Species：
Human (12)
Mouse (2)
Cynomolgus (1)
Rat (1)
Expression System：
HEK293 Cells (12)
Baculovirus Insect Cells (2)
E. coli (2)
Tag：
C-His (3)
C-His-Avi (3)
C-hFc (3)
His (2)
C-6xHis (1)
His, hFc (1)
N-6xHis (1)
N-His (1)
N-Trx, 6xHis (1)
Cat No. Product Name Species Expression System
TMPY-03305 VE-Cadherin Protein, Rat, Recombinant (His) Rat HEK293 Cells
VE-Cadherin Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 65.1 kDa and the accession number is A6JXX3.
TMPY-01677 VE-Cadherin Protein, Human, Recombinant (His & hFc) Human HEK293 Cells
VE-Cadherin Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 92 kDa and the accession number is P33151-1.
TMPY-01237 VE-Cadherin Protein, Mouse, Recombinant (His) Mouse HEK293 Cells
VE-Cadherin Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 63.5 kDa and the accession number is P55284.
TMPK-00359 Endoglin/CD105 Protein, Human, Recombinant (His & Avi) Human HEK293 Cells
Endoglin (CD105) is a 90 kDa type I transmembrane glycoprotein of the zona pellucida (ZP) family of proteins. Endoglin is a vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis...
TMPJ-00257 PSGL-1/CD162 Protein, Human, Recombinant (hFc) Human HEK293 Cells
PSGL-1 (CD162), is a mucintype glycoprotein that plays a key role in leukocyte adhesion. Human PSGL-1 cDNA encodes 412 amino acids (aa). It expressed on neutrophils, monocytes and most lymphocytes. The mature PSGL-1 (aa ...
TMPK-00350 E-Selectin/CD62E Protein, Human, Recombinant (His & Avi), Biotinylated Human HEK293 Cells
E-Selectin (Endothelial Leukocyte Adhesion Molecule-1, ELAM-1, CD62E), a member of the Selectin family, is a 107 - 115 kDa cell surface glycoprotein. It is transiently expressed on vascular endothelial cells in response ...
TMPK-00487 E-selectin/CD62E Protein, Cynomolgus, Recombinant (aa 22-554, His) Cynomolgus HEK293 Cells
E-Selectin (Endothelial Leukocyte Adhesion Molecule-1, ELAM-1, CD62E), a member of the Selectin family, is a 107 - 115 kDa cell surface glycoprotein. It is transiently expressed on vascular endothelial cells in response ...
TMPK-00349 E-Selectin/CD62E Protein, Human, Recombinant (His & Avi) Human HEK293 Cells
E-Selectin (Endothelial Leukocyte Adhesion Molecule-1, ELAM-1, CD62E), a member of the Selectin family, is a 107 - 115 kDa cell surface glycoprotein. It is transiently expressed on vascular endothelial cells in response ...
TMPJ-00361 Endoglin Protein, Human, Recombinant (Trx & His) Human E. coli
Endoglin is a single-pass type I membrane protein which restricted to endothelial cells in all tissues except bone marrow. Endoglin as major glycoprotein of vascular endothelium, it has been found on endothelial cells, a...
TMPJ-00379 AOC3 Protein, Human, Recombinant (hFc) Human HEK293 Cells
Membrane primary amine oxidase(AOC3), also known as vascular adhesion protein (VAP-1) and HPAO, this protein is a member of the semicarbazide-sensitive amine oxidase (SSAO) family. VAP-1 is a type 1 membrane-bound glycop...
TMPJ-00921 COL8A1 Protein, Human, Recombinant (His) Human HEK293 Cells
Collagen alpha-1(VIII) chain, also known as endothelial collagen, C3orf7 and COL8A1, can be cleaved into vastatin chain. COL8A1 is a short chain collagen and a major component of the basement membrane of the corneal endo...
TMPJ-00264 LAMP1 Protein, Human, Recombinant (hFc) Human HEK293 Cells
Lysosome-Associated Membrane Glycoprotein 1 (LAMP1) is a single-pass type I membrane protein belonging to the LAMP family. LAMP1 is expressed largely in the endosome-lysosome membranes of cells.It shuttles between lysoso...
TMPY-00410 EPHX2 Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
Genetic variation in EPHX2 was significantly associated with risk of incident CHD in Caucasians, implicating EPHX2 as a potential cardiovascular disease-susceptibility gene. Single nucleotide polymorphisms (SNPs) in the ...
TMPJ-00831 CCL3 Protein, Mouse, Recombinant (His) Mouse E. coli
C-C Motif Chemokine 3 (MIP-1 alpha,CCL3 ) is a member of the beta or CC subfamily of chemokines and is closely related to CCL4/MIP-1 beta. CCL3 expression can be induced in a variety of hematopoietic cells, fibroblasts, ...
TMPY-01052 R-Cadherin/CDH4 Protein, Human, Recombinant (His) Human HEK293 Cells
The cadherin superfamily is a large family that engage in both homo- and heterotypic, calcium-dependent, cell-cell adhesion events, and can be divided into at least four subfamilies based on the extracellular (EC) region...
TMPY-01345 ACBD6 Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
Human acyl-coenzyme A binding domain-containing member 6 (ACBD6) is a modular protein that carries an acyl-CoA binding domain at its N terminus and two ankyrin motifs at its C terminus. In mammals, there are six members ...
VE-Cadherin Protein, Rat, Recombinant (His)
TMPY-03305
Species: Rat
Expression System: HEK293 Cells
VE-Cadherin Protein, Human, Recombinant (His & hFc)
TMPY-01677
Species: Human
Expression System: HEK293 Cells
VE-Cadherin Protein, Mouse, Recombinant (His)
TMPY-01237
Species: Mouse
Expression System: HEK293 Cells
Endoglin/CD105 Protein, Human, Recombinant (His & Avi)
TMPK-00359
Species: Human
Expression System: HEK293 Cells
PSGL-1/CD162 Protein, Human, Recombinant (hFc)
TMPJ-00257
Species: Human
Expression System: HEK293 Cells
E-Selectin/CD62E Protein, Human, Recombinant (His & Avi), Biotinylated
TMPK-00350
Species: Human
Expression System: HEK293 Cells
E-selectin/CD62E Protein, Cynomolgus, Recombinant (aa 22-554, His)
TMPK-00487
Species: Cynomolgus
Expression System: HEK293 Cells
E-Selectin/CD62E Protein, Human, Recombinant (His & Avi)
TMPK-00349
Species: Human
Expression System: HEK293 Cells
Endoglin Protein, Human, Recombinant (Trx & His)
TMPJ-00361
Species: Human
Expression System: E. coli
AOC3 Protein, Human, Recombinant (hFc)
TMPJ-00379
Species: Human
Expression System: HEK293 Cells
COL8A1 Protein, Human, Recombinant (His)
TMPJ-00921
Species: Human
Expression System: HEK293 Cells
LAMP1 Protein, Human, Recombinant (hFc)
TMPJ-00264
Species: Human
Expression System: HEK293 Cells
EPHX2 Protein, Human, Recombinant (His)
TMPY-00410
Species: Human
Expression System: Baculovirus Insect Cells
CCL3 Protein, Mouse, Recombinant (His)
TMPJ-00831
Species: Mouse
Expression System: E. coli
R-Cadherin/CDH4 Protein, Human, Recombinant (His)
TMPY-01052
Species: Human
Expression System: HEK293 Cells
ACBD6 Protein, Human, Recombinant (His)
TMPY-01345
Species: Human
Expression System: Baculovirus Insect Cells
Cat No. Product Name
L7500 Coagulation and Anticoagulation Compound Library

144 compounds
A unique collection of 144 procoagulation and anticoagulation related compounds for high throughput screening (HTS) and high content screening (HCS);

Libraries

Coagulation and Anticoagulation Compound Library
L7500
Compounds: 144
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